Their last three winning margins in Anglo-Italian fixtures have been 37 points, 43 points and 31 points. Last weekend, of course, Franco Smith’s men went down 50-17in Ireland.
There are plenty of subplots this afternoon. Exeter Chiefs lock Jonny Hill makes a Test debut. Bath hooker Tom Dunn, Worcester centre Ollie Lawrence and Gloucester wing Ollie Thorley could do the same from the bench.
On the other end of the experience scale, Jamie George hits 50 caps for England and BenYoungs reaches three figures – a remarkable achievement. Livewire full-back Matteo Minozzi starts for Italy following his appearance in the Premiership final for Wasps.
He joinsa backline that will be steered by 20-year-old fly-half Paolo Garbisi, who made his Test debut in Dublin.
15 .Matteo Minozzi, 14. Edoardo Padovani, 13. Luca Morisi, 12. Carlo Canna, 11. Mattia Bellini, 10. Paolo Garbisi, 9. Marcello Violi; 1. Danilo Fischetti, 2. LucaBigi, 3. Giosue Zilocchi, 4. Marco Lazzaroni, Niccolo Cannone, 6. Sebastien Negri, 7. Braam Steyn, 8. Jake Polledri
Replacements: Gianmarco Lucchesi, 17. Simone Ferrari, 18. Pietro Ceccarelli, 19. David Sisi, 20. Johan Meyer, 21. Maxime Mbanda, 22. Gugliemo Palazzani, 23. Federico Mori
15. George Furbank, 14. Anthony Watson, 13. Jonathan Joseph, 12. Henry Slade, 11. JonnyMay, 10. Owen Farrell (captain), 9. Ben Youngs; 1. Mako Vunipola, 2. Jamie George, 3. Kyle Sinckler, 4. Maro Itoje, 5. Jonny Hill, 6. Tom Curry, 7. Sam Underhill, 8. Billy Vunipola
Replacements: 16. Tom Dunn, 17. Ellis Genge, 18. Will Stuart, 19. Charlie Ewels, 20. Ben Earl, 21. Dan Robson, 22. Ollie Lawrence, 23. Ollie Thorley